CD2 |
T cells, NK cells, thymocytes, and thymic B cell subsets |
T cell activation, adhesion |
|
|
✔ |
|
✔ |
|
|
CD3 |
Mature T and NK-T cells, thymocyte differentiation |
Antigen recognition, signal transduction, T cell activation |
✔ |
✔ |
|
✔ |
|
|
|
CD4 |
T cell subset, majority of thymocytes, monocytes/macrophages |
MHC class II co-receptor, lymphocyte adhesion, thymic differentiation, HIV receptor |
✔ |
✔ |
|
|
✔ |
✔ |
✔ |
CD5 |
Thymocytes, T cells, and subsets of B and dendritic cells. |
Modulates TCR and BCR signaling, involved in thymocyte maturation and T-B cell interaction |
✔ |
✔ |
|
|
|
|
|
CD7 |
T cells, NK cells, thymocytes, hematopoietic progenitors, myeloid leukemic cell subsets |
T cell activation |
✔ |
✔ |
|
|
|
|
|
CD8 |
Majority of thymocytes, T cell subset, NK cells |
MHC class I co-receptor, thymic differentiation, T cell activation |
✔ |
✔ |
|
|
|
✔ |
✔ |
CD10 |
B cell precursors, T cell precursors, neutrophils |
Zinc-binding metalloproteinase, B cell development |
|
✔ |
|
|
✔ |
|
|
CD11b |
Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells |
Adhesion, phagocytosis, chemotaxis, neutrophil activation |
✔ |
✔ |
|
|
|
|
|
CD13 |
Granulocytes, monocytes, myeloid progenitors, endothelial and epithelial cells, granular lymphocyte subset |
Zinc-binding metalloproteinase, antigen processing, cleaves MIP-1 chemokine |
|
✔ |
|
|
|
✔ |
|
CD14 |
Monocytes, macrophages, dendritic cells, and granulocytes |
LPS receptor, clearance of Gram-negative pathogens |
|
|
|
|
|
|
✔ |
CD15 |
Neutrophils, eosinophils, monocytes |
Adhesion |
✔ |
|
✔ |
|
|
|
|
CD16 |
NK cells, activated monocytes, macrophages, neutrophils |
Low affinity IgG Fc receptor, phagocytosis, ADCC |
✔ |
✔ |
|
|
|
|
✔ |
CD19 |
B lineage (except plasma cells), follicular dendritic cells |
B cell activation and differentiation |
✔ |
|
✔ |
|
✔ |
|
|
CD25 |
Activated T cells and B cells, monocytes/macrophages, Treg |
Associates with IL-2 receptor β (CD122) and γ chains (CD132) to form high affinity IL-2R complex |
|
|
|
|
✔ |
|
|
CD33 |
Myeloid progenitor, monocytes, granulocytes, dendritic cells, mast cells |
Adhesion and lectin activity |
|
✔ |
|
|
✔ |
✔ |
|
CD34 |
Hematopoietic stem/progenitor cells, bone marrow stromal cells, endothelial cells, embryonic fibroblasts |
Cell adhesion |
|
✔ |
|
|
|
|
|
CD38 |
T cells, B cells, NK, myeloid, plasma, and dendritic cells |
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation |
✔ |
|
|
|
|
✔ |
|
CD45 |
Hematopoietic cells, not expressed in circulating erythrocytes or platelets |
TCR and BCR mediated activation |
✔ |
|
|
✔ |
|
✔ |
|
CD45RA |
B cells, naïve T cells, monocytes |
Enhances TCR and BCR signaling |
✔ |
|
|
|
|
|
|
CD45RO |
Activated and memory T cells, B cell subsets, monocytes, macrophages, granulocytes |
Enhances TCR and BCR signaling |
|
✔ |
|
|
|
|
|
CD55 |
Hematopoietic cells including erythrocytes and many non-hematopoietic cells |
Protects against inappropriate complement activation and cell damage, induces signal transduction, reduces the efficiency of NK cell lysis |
✔ |
|
|
|
|
|
|
CD56 |
NK cells, T subset, neural tissue, some LGL and myeloid leukemias |
Adhesion |
|
✔ |
|
|
|
|
|
CD59 |
All cell types |
Blocks complement-mediated lysis by inhibiting MAC formation |
|
✔ |
|
|
|
|
|
CD64 |
Monocytes, macrophages, dendritic cells, activated granulocytes |
Phagocytosis, ADCC |
|
✔ |
|
|
|
|
|
CD71 |
Proliferating cells, reticulocytes, erythroid precursors |
Mediates uptake of iron |
✔ |
|
|
|
|
|
|
CD117 |
Pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, acute myeloid leukemic cells (AML) |
Growth factor receptor for stem cell factor. Induces proliferation and survival of primitive hematopoietic progenitors. Potent inducer of proliferation in erythroid-committed progenitor cells. Defects in CD117 have been linked to severe anemia and a decreased number of hematopoietic progenitor cells. |
|
✔ |
✔ |
|
|
|
|
CD127 |
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells |
T cell and immature B cell proliferation and development |
|
✔ |
|
|
|
|
|
HLA-DR |
B cells, activated T cells, monocytes/macrophages, dendritic cells, other APCs |
Peptide presentation |
✔ |
|
|
|
|
|
|
Kappa(Ig,k light chain) |
B cells |
/ |
✔ |
|
|
|
|
|
|
Lambda(Ig,λ light chain) |
B cells |
/ |
|
✔ |
|
|
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|
|